Could An Ordinary Childhood Vaccine Help Fight Covid-19?


 
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By Maggie Fox

A vaccine to prevent coronavirus may be months or even years away, but a team of researchers in the United States say an everyday vaccine that is available now might be used to help prevent the worst effects of coronavirus infection.

They're proposing giving a booster dose of the measles, mumps and rubella (MMR) vaccine to people to see if it ramps up immunity in general, perhaps helping prevent some of the most severe effects of Covid-19.

Their thinking: The MMR vaccine is known to protect kids against infections that go far beyond the three viruses targeted by the vaccine. The theory is that the vaccine boosts general immunity, in addition to training the body to recognize specific viruses.

The MMR vaccine is what's known as a live vaccine. It uses highly weakened, or attenuated, versions of the measles, mumps and rubella viruses to produce immune protection without making people sick. Because it uses whole viruses, it stimulates an immune response that is broad and goes beyond the production of antibodies.

"There is mounting evidence that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing 'trained' nonspecific innate immune cells for improved host responses against subsequent infections," Paul Fidel of Louisiana State University and Mairi Noverr of Tulane University wrote in a letter to the journal mBio.

"A clinical trial with MMR in high-risk populations may provide a 'low-risk--high-reward' preventive measure in saving lives during this unprecedented COVID-19 pandemic," they wrote. There's no serious risk to giving the vaccine to most people and the approach might be especially effective for protecting health care workers, they said.

"If we're wrong, well, at least people will have new antibodies to measles, mumps and rubella. So there's no harm, no foul," Fidel said.

"We emphasize this is strictly a preventive measure against the worst inflammatory sequelae of COVID-19 for those exposed/infected and does not represent an antiviral therapy or vaccine against COVID-19 in any manner," Fidel and Noverr added in their letter.

One theory about why children and teens have much lower rates of coronavirus infection is that they have more recently received vaccines, including MMR, than adults have, and have some of the residual extra immune benefits. Some countries are giving people booster shots of a tuberculosis vaccine for this reason, and some experts have proposed using polio vaccines for a similar purpose.

Some vaccine experts are dubious about the theory that children are less vulnerable to coronavirus because of recent vaccinations.

Dr. Peter Hotez, a pediatrics professor at the Baylor College of Medicine, said children could be less vulnerable because they have more recently been infected with some of the other coronaviruses that cause the common cold.

"This might stimulate local or systemic cross protecting immunity," Hotez said.

Or there's another possibility. "A more likely explanation is the lower expression of the ACE2 receptor in the upper respiratory tracts of children," said Dr. Paul Offit of the Children's Hospital of Philadelphia. The ACE2 receptor is a molecular doorway that is used by the new coronavirus to get into cells.



 
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    Editor-in Chief:
    Kirsten Nicole

    Editorial Staff:
    Kirsten Nicole
    Stan Kenyon
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    Kimberly McNabb
    Lisa Gordon
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    Stan Kenyon
    Liz Di Bernardo
    Cris Lobato
    Elisa Howard
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